(947153-64-2) palmatine chloride
Palmatine chloride
CAS: 10605-02-4
Molecular Formula: C21H22ClNO4
(947153-64-2) palmatine chloride - Names and Identifiers
| Name | Palmatine chloride |
| Synonyms | Palmatine HCL Palmatine chloride PALMATINE CHLORIDE BERBERICINE CHLORIDE PalMatin hydrochloride PALMATINE HYDROCHLORIDE (947153-64-2) palmatine chloride 2,3,9,10-TETRAMETHOXYPROTOBERBERINCHLORIDE 2,3,9,10-tetramethoxy-5,13a-dihydro-6H-isoquino[3,2-a]isoquinoline 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium chloride 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride |
| CAS | 10605-02-4 |
| InChI | InChI=1/C21H23NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,9-12,17H,7-8H2,1-4H3 |
(947153-64-2) palmatine chloride - Physico-chemical Properties
| Molecular Formula | C21H22ClNO4 |
| Molar Mass | 387.86 |
| Density | 1.25g/cm3 |
| Melting Point | 205℃ |
| Boling Point | 611.8°C at 760 mmHg |
| Flash Point | 184.1°C |
| Solubility | It is soluble in hot water, slightly soluble in water, slightly soluble in ethanol or chloroform, and almost insoluble in ether. |
| Vapor Presure | 6.6E-15mmHg at 25°C |
| Appearance | Yellow needle crystal |
| Color | Yellow |
| Storage Condition | Hygroscopic, Refrigerator, under inert atmosphere |
| Refractive Index | 1.624 |
| MDL | MFCD00016656 |
| Physical and Chemical Properties | It is soluble in hot water, slightly soluble in water, slightly soluble in ethanol or chloroform, and almost insoluble in ether. From the alkaloids proposed from the Chinese herbal medicine Huangteng. |
(947153-64-2) palmatine chloride - Risk and Safety
| Risk Codes | R20/22 - Harmful by inhalation and if swallowed. R36/38 - Irritating to eyes and skin. |
| HS Code | 29339900 |
(947153-64-2) palmatine chloride - Reference
| Reference Show more | 1. Chen Keyan, Feng Enfu, Huang Qian, Shen Mingli, Sima Quanwu, Jianghai, Zhang Huazhu, Xu Guili. Determination of Eglulostat in Rat Plasma by LC-MS/MS and Its Pharmacokinetics [J]. Chinese Journal of Clinical Pharmacology 2020 36(14):2127-2130. 2. Cao Yijia, Qu Yuxia, Sun Yu et al. Simultaneous Determination of 10 Compounds in Shalian Hewei Capsule by UPLC-MS/MS [J]. International Journal of Pharmaceutical Research 2020 v.47(01):76-81. 3. Chen Xuejian, Yang Mengling, Liu Wei, et al. Serum Pharmacochemistry Study on Effective Substance of Modified Xiaochaihu Decoction Against Gastric Ulcer [J]. Chinese Journal of Traditional Chinese Medicine 2018(8):1692-1700. 4. Chen Kai, Li Hui, Wang Jiaqi, Wang Yueyue, Song Mingming, Ding Chuanbo, Liu Yitong, Liu Wencong, Zheng Yinan. Based on the method of one test and multiple evaluation, the variation of compatibility ratio and pH value environment on the dissolution of four alkaloids after the compatibility of Coptis chinensis and Rhubarb [J]. Chinese herbal medicine, 2016,47(10):1709-1713. 5. Zhang Jiuxu, Fan Jing, Li Xiaoyang, et al. Research on Processing Methods of Coptis chinensis in Modern Origin Based on Internal Quality [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2019, v.21;No.185(09):74-77. 6. Li Tingxian, Li Meng, Zhang Zhi, eg. Evaluation of Quality Difference of Coptis chinensis and Its Procted Products Based on High Performance Liquid Chromatography Fingerprint and Infrared Spectrum [J]. Zhongnan Pharmacy, 2019, 017(004):556-560. 7. Wu Yichen, Xie Hui, Mao Chunqin, et al. HPLC Fingerprint of Compound Glycyrrhiza Qingyang Mixture [J]. Chinese patent medicine, 2019, 041(009):2251-2256. 8. Li Yajie, long Lan, Yang Yongkang, et al. Study on Quality Standard of Enshi Daodi Medicinal Coptis chinensis [J]. Journal of Hubei University for Nationalities: Natural Science Edition, 2012, 000(004):443-445. 9. Zhu Huimin, Li Li, Li Songya, et al. Establishment of Thin Layer Qualitative Identification and Content Determination Method of Berberis chinensis Root in Xinjiang [J]. Liaoning Journal of Traditional Chinese Medicine, 2019, v.46;No.509(10):132-136 230. 10. Wang Shuning, Zhu Hongyan, Gao Yugang, et al. Optimization of reflux extraction process of total alkaloids from Huangteng [J]. Chinese patent medicine, 2018, 040(006):1399-1403. 11. Zhang Xiao, Zhang Yali, Miao Xiangzhen, et al. Study on the correlation between the anti-tumor activity of different processed products and components of Coptis chinensis and the content of 6 alkaloids [J]. Chinese Journal of Traditional Chinese Medicine, 2019, v.34(06):350-353. 12. Zhang Chungang, Tang Jingya, Yu Chenchen, et al. Extraction, Purification and Content Determination of Five Major Alkaloids of Coptis chinensis [J]. Modern Chinese Medicine, 2018, 20(09):116-119 126. 13. Liu Yang, Yin Xiuwen, Wang Ziyu, et al. Study on Biopharmaceutical Classification System of Coptis chinensis Extract [J]. Chinese Journal of Traditional Chinese Medicine, 2017, 21(v.42):87-94. 14. Li Shujiao Wang Yuqing. HPLC-ABTS-DAD-Q-TOF/MS Online Screening of Antioxidant Active Substances of Coptis chinensis [J]. Chinese Journal of Traditional Chinese Medicine 2018(12). 15. Pi Wenxia Zhu Xinxian Fang Ting et al. HPLC Simultaneous Determination of Rhizine, Epicorberberine, Coptisine, Palmatine and Berberine in Various Purified Parts of "Three Heat Theory" Prescription [J]. Chinese Experimental Prescription [J]. Journal 2012 18(14):110-113. 16. Li Tingxian, Li Meng, Zhang Zhi, et al.. Determination of 6 alkaloids in different flavored decoction pieces by one test and multiple evaluation method [J]. Journal of Drug Analysis 2018 038(007):1132-1138. 17. Qiu Huihui, Han Ruiting, Sheng Lili, Li Houkai. Comparative Study on Prevention and Treatment of Nonalcoholic Fatty Liver Disease by Simaofang Granules and Decoction [J]. Chinese herbal medicine, 2021,52(04):1031-1038. 18. Wang Tingting, An Rui, Liang Kun, et al. Chemical Composition Analysis of Gegen Qinlian Decoction Based on UPLC-LTQ-Orbitrap High Resolution Mass Spectrometry [J]. Chinese herbal medicine, 2020(6):1498-1507. 19. Ji Wanli, Zhou Zehua, Wang Tingting, An Rui, Liang Kun, Wang Xinhong. Analysis of Chemical Constituents of Banxia Xiexin Decoction Based on UPLC-LTQ-Orbitrap-MS Methods [J]. Journal of Pharmaceutical Analysis, 2020,40(10):1736-1750. 20. Kang Nianxin, Yuan Yanyan, Zhang Xiao, Lu Yinghui, Li Qingxia, Li Fei, Tan Peng. Establishment of HPLC Characteristic Atlas, Cluster Analysis and Principal Component Analysis of Paetotrytis chinensis [J]. World Science and Technology-Modernization of Traditional Chinese Medicine, 2020,22(08):2790-2798. 21. Zhang, Y., Wang, Z., Xu, J. et al. Optimization of the extraction and purification of Corydalis yanhusuo W.T. Wang based on the Q-marker uniform design method. BMC Chemistry 14, 9 (2020). https://doi.org/10.1186/s13065-020-00666-6 22. Lvhuanwang, Yumei Zhao, Yanyan Zhang, tingting Zhang, Jeroen Kool, Govert W. Somsen, Qiqin Wang, Zhengjin Jiang, online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined wi 23. [IF = 4.759] Lvhuan Wang et al."Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry." J Chromatogr A. 2018 Aug;1563:135 24. [IF = 3.361] Yi Tao et al."Zeolite based solid-phase extraction coupled with UPLC-Q-TOF-MS for rapid analysis of acetylcholinesterase binders from crude extract of Corydalis yanhusuo." Rsc Adv. 2016 Oct;6(100):98476-98486 25. [IF = 6.4] Jing Zhao et al."Natural Nano-Drug Delivery System in Coptidis Rhizoma Extract with Modified Berberine Hydrochloride Pharmacokinetics." Int J Nanomed. 2021; 16: 6297-6311 26. [IF = 5.645] Xiaojin Peng et al."Development of a novel functionality for a highly efficient imidazole-based ionic liquid non-aqueous solvent system for the complete extraction of target alkaloids from Phellodendron amurense Rupr. under ultrasound-assisted conditions. 27. [IF = 3.935] Meng Chen et al." Comprehensive analysis of Huanglian Jiedu decoction: revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate."J Pharmaceut Biomed. 2021 Feb;195:113820 28. [IF = 3.004] Kai Zhang et al." Untargeted metabolomics reveals the synergistic mechanisms of Yuanhu Zhitong oral liquid in the treatment of primary dysmenorrhea."J Chromatogr B. 2021 Feb;1165:122523 |
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